Arotrix-C 5%+10% is a Product of the Generic Permethrin + Crotamiton

What Is Arotrix-C 5%+10% Indications and Uses?

Arotrix-C 5%+10% (Permethrin + Crotamiton) lotion is indicated for the treatment of scabies and pruritus. Moreover, it is used for the relief of itching and skin irritation like as sunburn, dry eczema, itchy dermatitis, allergic rashes, hives, nettle rash, chickenpox, insect bite and stings, heat rashes and personal itching.

Pharmacology (Source, Chemical and Physical Composition) Of Arotrix-C 5%+10%

This is a combination of Arotrix-C 5%+10% (Permethrin + Crotamiton) which is a photostable synthetic pyrethroid that possesses a broad spectrum of insecticidal activity and low mammalian toxicity and Crotamiton which is used to treat scabies infection. It is also used to relieve the itching of certain skin conditions. Mode of action : The insect rapidly absorbs Permethrin via mouth, respiratory tract or the intact cuticle. Although the primary target tissue is the nervous system, insects are not killed by dysfunction of a single organ but by a complex series of reactions in various organs, such as metabolic exhaustion and paralysis of the nervous system. Permethrin primarily affects sodium channels in the nerve membrane and causes prolongation of the transient increase in sodium permeability associated with membrane depolarization. After treatment with permethrin, the sodium current is evoked by a step depolarization of the membrane. This leads to sensory hyperexcitability, incoordination and prostration. It is assumed that mode of action against mites is similar. Pharmacokinetics : The only approved route of administration is the topical route and there are few human data available on systemic exposure or kinetics following permethrin application to the skin. Some presystemic metabolism occurs in skin. Less than 0.5% of applied permethrin is absorbed during the first 48 hours. Absorbed permethrin is rapidly metabolized by ester hydrolysis, most likely in the liver and the products are excreted primarily in the urine. Crotamiton penetrates rapidly into human skin. Low but measurable concentrations of crotamiton are found in plasma, with a maximum level after 4-10 hours, declining rapidly thereafter.

Drug Interactions of Arotrix-C 5%+10%

The treatment of eczematous-like reactions with corticosteroids should be withheld prior to treatment with Arotrix-C 5%+10% (Permethrin + Crotamiton) and Crotamiton lotion, as there is a risk of exacerbating the scabies infestation by reducing the immune response to the mite.

Side Effects of Arotrix-C 5%+10%

In scabies patients, skin discomfort, usually described as burning, stinging or tingling occurs in a few individuals soon after the lotion is applied. Other transient signs and symptoms of irritation including erythema, edema, eczema and rash which may follow the treatment of scabies with Arotrix-C 5%+10% (Permethrin + Crotamiton) and Crotamiton lotion are generally considered to be the part of the natural history of scabies.

Precautions And Warnings for Arotrix-C 5%+10%

Nursing staff, who routinely apply Arotrix-C 5%+10% (Permethrin + Crotamiton) and Crotamiton lotion, may wear gloves to avoid any possible irritation to the hands. Avoid contact with the eyes. The lotion can cause eye irritation. If lotion goes to the eye, rinse with water immediately.

Use During Pregnancy and Lactation

There is no experience to judge the safety of Arotrix-C 5%+10% (Permethrin + Crotamiton) and Crotamiton in pregnancy, therefore it is not recommended during pregnancy, especially in the first three months. It is not known whether the active substance passes into breast milk. Nursing mothers should avoid applying it in the area of the nipples.

Therapeutic Class

Local Antipruritic, Parasiticidal preparations

Storage Conditions of It

Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light. Pack Image: Arotrix-C 5%+10% Lotion Thanks for using MedEx! How would you rate your experience so far?