Aric 20 mg is a Product of the Generic Istradefylline

Aric 20 mg belongs to the generic category of Istradefylline. This medicine should be used according to a doctor's advice. We have provided detailed information about the uses, dosage, effectiveness, side effects, precautions, drug interactions, storage conditions, and other important details of Aric 20 mg. Our goal is to present essential medicine information in one place for patients, caregivers, and healthcare professionals. To better understand Istradefylline and ensure the safe use of this medicine, please read the information below carefully and consult a healthcare professional when necessary.

Description of Aric 20 mg

Aric 20 mg may be available as a prescription or over-the-counter medicine, depending on local regulations and medical recommendations. It is used for the treatment and management of specific conditions or symptoms. The way this medicine is used may vary depending on the patient's condition and the advice of a healthcare provider. Detailed information about the approved uses, therapeutic applications, and other relevant details of Aric 20 mg is provided below to help users gain a clear understanding of this medicine.

What Is Aric 20 mg Indications and Uses?

Istradefylline tablet is an adenosine receptor antagonist indicated as adjunctive treatment to levodopa/carbidopa in adult patients with Parkinson's disease experiencing "off" episodes.

Pharmacology (Source, Chemical and Physical Composition) Of Aric 20 mg

Istradefylline is a selective adenosine A2A receptor inhibitor. These receptors are found in the basal ganglia, a region of the brain that suffers degeneration in Parkinson's disease, and is also significantly involved in motor control. A2A receptors are also expressed on GABAergic medium spiny neurons within the indirect striato-pallidal pathway. The GABAergic action of this pathway is thereby reduced. Istradefylline has 56 times the affinity for A2A receptors than A1 receptors.

Dosage And Administration of Aric 20 mg

The recommended dosage of Istradefylline is 20 mg administered orally once daily. The dosage may be increased to a maximum of 40 mg once daily, based on individual need and tolerability. Patients who smoke 20 or more cigarettes per day (or the equivalent of another tobacco product) the recommended dosage is 40 mg once daily.Patients with Hepatic Impairment: Maximum recommended dosage with moderate hepatic impairment is 20 mg once daily, use of Istradefylline in patients with severe hepatic impairment should be avoided.Use in Children: Safety and effectiveness of Istradefylline in pediatric patients have not been established.

Drug Interactions of Aric 20 mg

The recommended maximum dosage of Istradefylline with concomitant use of strong CYP 3A4 inhibitors (Ketoconazole) is 20 mg once daily and avoid use with strong CYP 3A4 inducers (Rifampicin).

Side Effects of Aric 20 mg

The most common adverse reactions of Istradefylline are dyskinesia, dizziness, constipation, nausea, hallucination, and insomnia.

Use During Pregnancy and Lactation

Use of Istradefylline during pregnancy is not recommended. Based on studies it may cause fetal harm. There are no data on the presence of Istradefylline in human milk, the effects of Istradefylline on the breastfed infant, or on milk production. Caution should be exercised when administered to a nursing woman.

Precautions And Warnings for Aric 20 mg

Monitor patients for dyskinesia or exacerbation of existing dyskinesia. If hallucinations / psychotic behavior / impulse control / compulsive behaviors occurs then consider dosage reduction or stop Istradefylline.

Therapeutic Class

Antiparkinson drugs

Storage Conditions of It

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Aric 20 mg is a Product of the Generic Istradefylline

Aric 20 mg

Incepta Pharmaceuticals Ltd. · Tablet

Istradefylline