Amifen 500 mg is a Product of the Generic Mefenamic acid

What Is Amifen 500 mg Indications and Uses?

Mefenamic Acid is indicated for-

Fever
Toothache
Headache
Migraine
Primary dysmenorrhoea
Menorrhagia
Mild to moderate pain in rheumatoid arthritis and osteoarthritis
Traumatic pain
Low-back pain
Juvenile chronic arthritis in children etc.

Pharmacology (Source, Chemical and Physical Composition) Of Amifen 500 mg

Mefenamic acid contains Mefenamic Acid which is a nonsteroidal agent with demonstrated analgesic, anti-inflammatory and antipyretic activity due to its dual action on prostaglandins. It inhibits the enzymes of prostaglandin synthetase and also antagonizes the actions of prostaglandin at the receptor sites.

Dosage And Administration of Amifen 500 mg

Adult:

500 mg dose should be given to adults upto three times (1.5 gm total) per day with meals. The dosage may be reduced to 1 tablet (250 mg) three times daily.
In case of menorrhagia: 500 mg three times daily with meals and from the onset of menses and continued according to the judgement of the physician.

Children:

6 months to 1 year: 5 ml three times/day.
2-4 years: 10 ml three times/day.
5-8 years: 10 ml four times /day.
9-12 years: 15 ml four times/day.

Treatment should not be continued for more than 7 days except on the advice of a physician.

Drug Interactions of Amifen 500 mg

Aspirin: As other NSAIDs, concomitant administration of Mefenamic Acid and Aspirin is not generally recommended because of the potential of increased adverse effects.Warfarin: Mefenamic Acid can inhibit platelet aggregation and may prolong the prothrombin time in patients on warfarin therapy

Side Effects of Amifen 500 mg

The most frequently reported adverse experiences occurring in approximately 1-10% of patients are gastrointestinal: abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, nausea, Gl ulcers, vomiting, dizziness, abnormal renal function, pruritus, rashes.

Use During Pregnancy and Lactation

The safety of Mefenamic acid on reproductive capacity and pregnancy has not been established. Thus, mefenamic acid should be used in women of childbearing potential and during pregnancy only when the potential benefits are expected to outweigh the potential risks. Trace amounts of Mefenamic acid may be present in breast milk and transmitted to the nursing infant. Thus Mefenamic acid should not be taken by the nursing mother because of the effects of this class of drugs on the infant's cardiovascular system.

Precautions And Warnings for Amifen 500 mg

It should be administered with caution in allergic diseases especially in asthma. The treatment should be withdrawn in diarrhoea, rashes, cholestatic jaundice, thrombocytopenia, haemolytic anaemia.

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions of It

Keep away from light, store in a cool and dry place. Keep out of reach of children.