OTC

Amenavir 200 mg

Square Pharmaceuticals PLC · Tablet

GenericAmenamevir

Strength200 mg

Total Strip1

Strip Size7

Unit Price

৳ 150

/ Piece

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The information provided on All Samadhan is intended for general informational purposes only and is prepared based on our best practices. It is not a substitute for professional medical advice, diagnosis, or treatment. While we strive to keep the information accurate and up to date, we do not guarantee its completeness or accuracy. The absence of specific information or warnings about any medicine or service should not be considered as an assurance or endorsement by All Samadhan. All Samadhan shall not be held responsible for any consequences arising from the use of this information. We strongly recommend consulting a qualified healthcare professional or physician for any medical concerns, questions, or clarifications.

Medicine Description

INDICATIONS

Amenamevir tablet is indicated for the treatment of herpes simplex, recurrent herpes simplex and herpes zoster. Its unique mechanism of action makes it a potential alternative for patients who have developed resistance to other antiviral medications.

PHARMACOLOGY

Amenamevir works by inhibiting the viral helicase-primase complex, an enzyme essential for unwinding the viral DNA and synthesizing primers during viral DNA replication. This mechanism is distinct from traditional antiviral drugs like acyclovir and valaciclovir, which target viral DNA polymerase.

DOSAGE & ADMINISTRATION

Herpes simplex: The usual adult dosage of Amenavir is 200 mg administered orally once daily after meal. Recurrent herpes simplex: 1200 mg single dose after meals within 6 hours after the appearance of the initial symptoms of recurrent herpes simplex. (Only one dose is required). Herpes zoster: The usual adult dosage of Amenavir is 400 mg administered orally once daily after meal.Use in children: There is a lack of specific clinical studies evaluating the safety and efficacy of Amenamevir in children.

INTERACTION

Amenamevir has notable interactions with certain drugs due to its metabolism via cytochrome P450 enzymes, particularly CYP3A4.Ketoconazole: As a strong CYP3A4 inhibitor, Ketoconazole significantly increases the plasma concentration of Amenamevir.Rifampicin:This strong CYP3A4 inducer markedly decreases Amenamevir levels, that could lead to reduced efficacy of Amenamevir.Midazolam: As a substrate of CYP3A4, Midazolam's pharmacokinetics are affected by Amenamevir, leading to decreased plasma levels when both are taken together.Warfarin: No significant interaction was observed between Amenamevir and Warfarin, a medication metabolized by CYP2C9.

SIDE EFFECTS

Common Side Effects are Headache, Nausea, Diarrhea, Abdominal Pain, Skin Reaction, increased N-acetyl-(M>glucosaminidase and a1-microglobulin levels Serious Side Effects are Thrombocytopenia, Gingival Bleeding, Palpitations.

PREGNANCY & LACTATION

Pregnancy: Animal studies in mice and rabbits showed no adverse effects on maternal animals or fetal development at certain doses. However, the report does not provide specific recommendations regarding the safety of Amenamevir in pregnant women.Lactation: There is no specific information about the use of Amenamevir during breastfeeding.