Acin 150 mg

Indications
Treatment of an active duodenal ulcer with ranitidine

Gastric ulcer that isn't harmful
The use of a non-steroidal anti-inflammatory drug in the treatment and prevention of ulcers
Stress ulcer after surgery.
The Zollinger-Ellison Syndrome is a condition that affects people.
Gastroesophageal reflux disease (GERD) is a type of gastroesophageal reflux (GERD).
Stress ulcer causes a gastrointestinal bleeding in a critically unwell patient.
Patients with a bleeding peptic ulcer may experience recurrent haemorrhage.
Before undergoing general anesthesia in individuals who are at risk of acid
aspiration, such as obstetric patients.



Pharmacology
Ranitidine decreases stomach acid output by competitively blocking histamine at H2-receptors in the gastric parietal cells. Pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, and serum gastrin are unaffected.



Dosage & Administration
Ranitidine Tablet & Syrup:
Duodenal and gastric ulcer: The usual dosage is 150 mg twice daily taken in the morning and evening or 300 mg as a single daily dose at night for 4 to 8 weeks.

Reflux oesophagitis: 150 mg twice daily or 300 mg at bed time for up to 8 weeks

Zollinger Ellison syndrome: 150 mg 3 times daily and increased if necessary up to 6 g daily in divided doses. Dosage should be continued as long as clinically indicated.

Episodic dyspepsia: 150 mg twice daily or 300 mg at bed time for up to 6 weeks.

Maintenance: 150 mg at night for preventing recurrences.

Child (peptic ulcer): 2-4 mg/kg twice daily, maximum 300 mg daily.


Ranitidine IV injection & IV Infusion:
Ranitidine injection may be given either as a slow (over a period of at least two minutes) intravenous injection of 50 mg, after dilution to a volume of 20 ml per 50 mg dose, which may be repeated every six to eight hours; or as an intermittent intravenous infusion at a rate of 25 mg per hour for two hours; the infusion may be repeated at six to eight hour intervals; or as an intramuscular injection of 50 mg (2 ml) every six to eight hours. In the prophylaxis of haemorrhage from stress ulceration in seriously ill patients or the prophylaxis of recurrent haemorrhage in patients bleeding from peptic ulceration, parenteral administration may be continued until oral feeding commences.

In the prophylaxis of upper gastrointestinal haemorrhage from stress ulceration in seriously ill patient sapriming dose of 50 mg as low as intravenous injection followed by a continuous intravenous infusion of 0.125-0.250 mg/kg/hour may be preferred. In patients considered to be at risk of developing aspiration syndrome Ranitidine injection 50 mg may be given intramuscularly or by slow intravenous injection 45 to 60 minutes before induction of general anaesthesia.

Children: The recommended oral dose for the treatment of peptic ulcer in children is 2 mg/kg to 4 mg/kg twice daily to a maximum of 300 mg ranitidine per day. Safety and effectiveness of Ranitidine injection have not been established in case of children.



Interaction
Propantheline bromide delayed absorption and raised peak serum levels. Ranitidine has a minor inhibitory effect on the hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propanolol. pH-dependent medication absorption may be affected (e.g. ketoconazole, midazolam, glipizide). Antacids may decrease bioavailability.



Contraindications
Patients who are allergic to ranitidine



Side Effects
Ranitidine is generally well tolerated, with little adverse effects. Changes in bowel habits, dizziness, rash, fatigue, reversible confusional episodes, headache, reduced blood counts, and muscular or joint pain have been observed seldom.



Pregnancy & Lactation
Ranitidine crosses the placenta during pregnancy. However, there is no proof that Ranitidine causes infertility or damage to the fetus. Ranitidine, like other medications, should only be taken during pregnancy if absolutely necessary.

Ranitidine is secreted in human breast milk during lactation. When administering the medication to a nursing mother, extreme caution should be used.



Precautions & Warnings
Patients with poor renal and hepatic function should be administered ranitidine at a lower dose.



Therapeutic Class
H2 receptor antagonist



Storage Conditions
Keep in a cool, dry place. shield against the sun.



Pharmaceutical Name
Biopharma Laboratories Ltd.